Clinical Trials for Brain Tumors

201411046

Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma (BN001) Phase II Principal Investigator Huang, Jiayi…

201509033

Computer-based Neurocognitive Assessment in Children with Central Nervous System Tumors Receiving Proton Beam Radiation Therapy Phase N/A Principal Investigator Perkins, Stephanie Disease Site Brain and Nervous System; Pediatric Cancers Learn more about this study at:…

201512009

A Phase I and Pilot Study of the Effects of rhIL-7-hyFc (NT-17) on CD4 Counts in Patients with High Grade Gliomas and Severe Treatment-Related CD4 Lymphopenia after Concurrent Radiation and Temozolomide Phase I Principal Investigator…

201604115

A phase I/II dose-escalation and dose-expansion study of disulfiram/copper with concurrent radiation therapy and temozolomide in patients with newly diagnosed glioblastoma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201707047

Phase III Trial of Observation vs Irradiation for a Gross Totally Resected Grade II Meningioma Phase III Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201709026

A Phase II Randomized Trial of Proton vs Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas Phase II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous…

201709055

Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas Phase II Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201711195

A Phase Ib Study of Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma Phase I Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this…

201806093

Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma Phase II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this…

201808111

Protocol CCTG CE.7, A Phase III Trial of Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases Phase III Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System…

201809080

A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy STELLAR Study…

201809175

Novel Approach of Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation after Cancer-related Cord Compression Phase II Principal Investigator Gay, Hiram Disease Site Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Anus; Bone Marrow…

201810185

Effect of rhIL-7-hyFc on increasing lymphocyte counts in patients with newly diagnosed non-severe lymphopenic gliomas following radiation and temozolomide Phase I/II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this…

201901009

A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201903023

Pilot Study of Same-session MR-only Simulation and Treatment with Stereotactic MRI-guided Adaptive Radiotherapy (SMART) for Oligometastases of the Spine Phase N/A Principal Investigator Henke, Lauren Disease Site Brain and Nervous System Learn more about this…

201905095

GBM AGILE Phase II/III (Cancer Control) Principal Investigator Ansstas, George Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201908018

Mapping Draining Lymph Nodes in CNS Malignancies Phase I Principal Investigator Dunn, Gavin Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201908176

AVATAR anesthesia alternative in pediatric radiotherapy: A Multi-Trial Pilot Study Phase N/A Principal Investigator Perkins, Stephanie Disease Site Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Anus; Bone Marrow Transplant; Bones and Joints; Brain and…

201911203

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease Phase III (Cancer Prevention) Principal Investigator Abraham, Christopher Disease Site Brain and Nervous System; Metastatic…

202003050

Safety and efficacy study of INCMGA00012 and epacadostat in combination with radiation and bevacizumab in patients with recurrent gliomas Phase II Principal Investigator Campian, Jian Disease Site Brain and Nervous System Learn more about this…

202003064

Phase I/II Study of Pamiparib (BGB-290) with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations Phase I/II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

202003072

A Pilot Study to Assess the Safety, Feasibility, and Immunogenicity of a Neoantigen-based Personalized DNA Vaccine in Patients with Newly Diagnosed, Unmethylated Glioblastoma Phase I Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System…

202009128

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of PRT811 in Subjects with Advanced Solid Tumors, CNS Lymphoma, and Recurrent High-Grade Gliomas Phase I (Cancer Control) Principal Investigator Johanns, Tanner Disease Site Brain…

202012017

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1 Phase III (Cancer Control) Principal Investigator…

202012180

A PHASE II STUDY OF CHECKPOINT BLOCKADE IMMUNOTHERAPY IN PATIENTS WITH SOMATICALLY HYPERMUTATED RECURRENT GLIOBLASTOMA Phase II Principal Investigator Dunn, Gavin Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

202103257

A phase IB study to use tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wildtype grade III-IV astrocytoma Phase I Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this study at:…